Neuropathic pain (neuralgia) is a pain that comes from problems with signals from the nerves. It was mainly classified into peripheral neuropathic pain that includes Radiculopathy and other peripheral disorder and central neuropathic pain which includes spinal cord injury and central disorders. Pain is a significant public health problem that costs society at least $560-$635 billion annually. The annual USA direct medical costs attributable to migraine were estimated at $1 billion in 1999.Women was more likely to experience pain in comparison to men. The percentage of public experiencing migraines or severe headaches was inversely related to age. About 20 % of adults aged 18-44 years experienced a migraine or severe headache where 15% of adults aged 45-64, 7% of adults aged 65-74, and 6% of adults aged 75 and over. In the year 2008 prescription painkiller overdoses killed nearly 15,000 people in the USA. According to the recent survey, Chronic Pain affects 47% of USA Adults. The main intent of this session is to understand Complex regional pain syndrome (CRPS) that is associated with dysregulation of Central Nervous System (CNS) and Autonomic Nervous System (ANS). Apart from CRPS the autoimmune antibodies involved in the Pathophysiology causes auto immune neuropathic pain. Along with this we will also discuss about Post stroke pain, Diagnostic procedure for neuropathic pain and psychoactive drugs and pain management.